Hello @YigalB yes, the I2C address is stored in flash. There is no need to repeat that step (changing I2C address) after every power up. It just needs to be done once. Alternatively you can use a PaHub like @teastain suggested. Thanks Felix

@YigalB FreeRTOS is baked in. All four are GPIO. The drawing has a minor notation error and to simplify things for new Users there is a suggestion that Port A, red, is I2C and Port B, black, is one in and one out. But they are all General Purpose Input-Output. https://www.espressif.com/sites/default/files/documentation/esp32-s3_datasheet_en.pdf page 16 I/O mux